Octreotide Acetate

Product Introduction:

Product Name: Octreotide Acetate

Product Source: Chemically synthesized (artificially synthesized somatostatin analog)

Content Specifications: Injection: 0.05mg/1mL, 0.1mg/1mL, 0.2mg/1mL, 0.5mg/1mL, 1mg/5mL;

Microsphere sustained-release preparation: 10mg, 20mg, 30mg/bottle

CAS Number: 83150-76-9

Detection Method: HPLC

Active Ingredient: Octreotide Acetate

Product Characteristics: White to off-white lyophilized powder or sustained-release microsphere preparation

Product Uses: 1. Treatment of acromegaly;

2. Symptom control of neuroendocrine tumors;

3. Acute hemostasis for esophageal and gastric variceal bleeding;

4. Auxiliary treatment of pancreatic fistula and intestinal fistula.

Product Storage: Refrigerate at 2-8°C, protected from light (unopened)

Shelf Life: 24-36 months (unopened, specific period as indicated on packaging)

Products  Description  

 Xi'an Tihealth high-purity Octreotide Acetate

Tihealth adopts an international standard production system to ensure stable product purity>99.5% (HPLC detection), endotoxin<5EU/mg, and moisture content<5.0%. Our freeze-dried powder formulation has excellent batch stability and solubility, strictly meeting various standard requirements. The product can meet the full cycle needs of pharmaceutical companies from raw material application to commercial production. With strict quality control and flexible supply chain. Tikangyuan will provide you with a stable supply service of octreotide acetate raw materials

Products Function

Octreotide acetate is an artificially synthesized somatostatin analog, and its core biological activity is:

✅ Efficient inhibition of various pituitary hormones and exocrine substances (such as growth hormone GH, insulin, glucagon, gastrin, etc.)

✅ Regulating the release of vasoactive substances (such as serotonin and vasoactive intestinal peptide VIP)

✅ Inhibit pathological cell proliferation (some neuroendocrine tumor cells)

Note: The raw material itself does not directly produce clinical efficacy and needs to be made into a formulation to exert its effect.

Mechanism of action

Plays a role by selectively binding to the somatostatin receptor (SSTR2/SSTR5 subtype):

① Inhibit hormone secretion: block adenylate cyclase, reduce cAMP levels, and decrease hormone release;

② Inhibiting cell proliferation: activating tyrosine phosphatase and blocking growth factor signaling pathways;

③ Reduce visceral blood flow: contract the smooth muscle of visceral arteries, reduce portal vein blood flow (key to hemostasis).

Products Aplication

As an active pharmaceutical ingredient, it is mainly used in the production of the following therapeutic preparations:

<!--[if !supportLists]-->1. <!--[endif]-->Intravenous/subcutaneous injection:

- Acute esophageal-gastric variceal bleeding caused by liver cirrhosis (lowering portal pressure)

- Symptom control of gastrointestinal and pancreatic neuroendocrine tumors (such as carcinoid syndrome, VIPoma)

- Adjuvant treatment after surgery or radiotherapy for acromegaly (lowering GH and IGF-1 levels)

<!--[if !supportLists]-->2. <!--[endif]-->Long-acting sustained-release microsphere formulation:

- Chronic diseases requiring long-term medication (such as acromegaly, metastatic neuroendocrine tumors)

Pharmacological effects:

The pharmacological effects of octreotide acetate include:

- Inhibit the secretion of hormones such as growth hormone, glucagon, insulin, etc.

- Reduce visceral blood flow and inhibit the secretion of peptide hormones in the gastrointestinal pancreatic (GEP) endocrine system.

- Promote bile excretion and improve cholestatic liver disease.

- By inhibiting pancreatic secretion, reducing the secretion of digestive enzymes and bicarbonate, diarrhea can be controlled.

- Reduce portal hypertension, constrict visceral vascular bed, and decrease portal venous blood flow.

Key characteristics of active pharmaceutical ingredients

-- High purity ensures activity:>99.5% purity (HPLC) ensures receptor binding efficacy

-- Low endotoxin control:<5 EU/mg, meeting the safety requirements for injections

-- Batch stability: strict temperature and humidity control, shelf life up to 24 months